Description:
BURKITT LYMPHOMA; BL
|
Repository
|
NIGMS Human Genetic Cell Repository
|
| Subcollection |
Heritable Diseases
Chromosome Abnormalities
dbGaP |
| Class |
Heritable Cancer Syndromes and other Cancers |
| Alternate IDs |
GM17349 [BURKITT LYMPHOMA; BL] |
| Quantity |
25 µg |
| Quantitation Method |
Please see our FAQ |
|
Biopsy Source
|
Peripheral vein
|
|
Cell Type
|
B-Lymphocyte
|
|
Tissue Type
|
Blood
|
|
Transformant
|
Epstein-Barr Virus
|
|
Sample Source
|
DNA from LCL
|
|
Race
|
Black/African American
|
|
Ethnicity
|
AFRICAN
|
|
Relation to Proband
|
proband
|
|
Confirmation
|
Clinical summary/Case history
|
|
ISCN
|
46,XY,t(8;22)(q24;q11),der(11)t(11;16)(q23.2;q21)[43] / 47,XY,+7, +der(1)t(1;16)(p13;p12),-16,t(8;22),dic(10;16)(p15;p12),der(11)t(11;16)(q23.2;q21)[17].ish t(8;22)(myc+;myc+)
|
|
Species
|
Homo sapiens
|
|
Common Name
|
Human
|
|
Remarks
|
|
| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis |
| |
| Cytogenetics |
Chromosome 22: TRANSLOCATION Breakpoint 22q11 t(8;22)22q11 |
|
Chromosome 8: TRANSLOCATION Breakpoint 8q24 t(8;22)8q24 |
| Remarks |
Line IARC/LY47; Ugandan; 46,XY,t(8;22) (8pter>8q24::22q11>22qter;22pter>22q11:: 8q24>8qter); 68% of cells were 47,XY,+7, +der(1)t(1;16),-16,t(8;22),t(10;16) |
| Bernheim A, Berger R, Lenoir G, Cytogenetic studies on African Burkitt's lymphoma cell lines: t(8;14), t(2;8) and t(8;22) translocations. Cancer Genet Cytogenet3:307-15 1981 |
| PubMed ID: 7260888 |
|
|